October 01, 2008
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Study identifies factors related to severity of retinopathy in preeclampsia

A retrospective study has identified a significant association between placental insufficiency, intrauterine growth retardation and the severity of retinopathy in women with preeclampsia. In addition, the investigators found that retinopathy severity may function independently of systemic blood pressure.

Arvind Gupta, MS, and colleagues evaluated the possible associations between retinopathy, systolic and diastolic blood pressure, fetal birth weight and other biochemical parameters from medical records of 40 patients with preeclampsia and a control group of 40 patients with pregnancy-induced hypertension who delivered at term.

Among patients with preeclampsia, the investigators identified an inverse association between retinopathy and fetal birth weight (P = .044) and a positive association between retinopathy severity and serum uric acid level (P = .022).

However, systolic blood pressure, diastolic blood pressure and all other variables had no significant association with retinopathy in these patients, the authors reported.

"In the [control] group, none of the parameters analyzed were significantly associated with ocular changes," the study authors said in the September issue of Retina.