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Study identifies device-generated parameters that distinguish glaucomatous, normal eyes

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Parameters generated by the Ocular Response Analyzer may be useful for distinguishing between patients with and without primary open-angle glaucoma, according to a retrospective study, published in the June issue of Optometry and Vision Science.

"Furthermore, the discriminatory power of each [Ocular Response Analyzer, Reichert] variable seems to depend on the diagnostic groups that are being compared," the study authors said.

Michael Sullivan-Mee, OD, and colleagues compared age, ethnicity, Goldmann IOP measurements, central corneal thickness and Ocular Response Analyzer-derived biomechanical data for right eyes of 298 patients who demonstrated acceptable Ocular Response Analyzer signal profiles. Specifically, 71 eyes were normal, 58 eyes had ocular hypertension, 70 eyes were deemed glaucoma suspect and 99 eyes had primary open-angle glaucoma.

Using variance analysis, the investigators found a higher mean age, a higher mean difference between corneal-compensated IOP and Goldmann-correlated IOP, and a lower mean corneal hysteresis in the primary open-angle glaucoma group than all other groups.

Using multivariate regression analyses, they found that age, corneal-compensated IOP, and the difference between corneal-compensated IOP and Goldmann-correlated IOP independently discriminated between glaucomatous and normal eyes.

In addition, age and corneal-compensated IOP independently discriminated between glaucomatous and glaucoma suspect eyes, while age and corneal resistance factor independently discriminated between eyes with glaucoma and ocular hypertension, according to the study.

However, when distinguishing between glaucomatous and normal eyes, the investigators found that corneal hysteresis replaced the difference between corneal-compensated IOP and Goldmann-correlated IOP with "nearly equal statistical power."