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Study finds more transient inflammation with tinted AcrySof IOL in children

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Children implanted with the blue light-filtering version of the AcrySof IOL showed significantly higher rates of transient postoperative inflammation than children who received the standard nontinted lens, a study by Texas researchers found.

However, both lenses were associated with similar rates of nontransient sequelae, including posterior capsular opacification, the study authors noted.

Cynthia L. Beauchamp, MD, and colleagues at the University of Texas Southwestern Medical Center, Dallas, reviewed records for 29 eyes of 21 children implanted with the AcrySof Natural model SN60AT (Alcon) and compared their outcomes with 38 eyes of 31 children implanted with the standard AcrySof model SA60AT (Alcon).

Children were followed for an average of 5 months postop in the tinted lens group and for an average of 8 months postop in the standard lens group. Both groups were similar in age, according to the study.

The researchers found a fairly high incidence of postoperative inflammation in both groups — 69% in the tinted lens group and 55% in the standard lens group. However, patients in the tinted lens group had a 38% incidence of transient inflammation, including fibrinous reaction, resolved fibrinous membranes and flare, significantly higher than the 16% incidence seen in the standard lens group, the authors reported.

Both groups showed similar rates of nontransient sequelae, including posterior synechiae, iris synechiae, fibrinous membranes, secondary membranes and IOL or capsular opacification. Such inflammatory signs occurred in 66% of the tinted lens group and in 47% of the standard lens group, according to the study.

"The rate of posterior capsule opacification was relatively high in both groups, and while higher in the tinted lens group, there was no difference in the incidence of opacification that was visually significant," the authors noted.

"Given its similarity to the SA60AT, the cause of the higher incidence of transient inflammation seen in our tinted lens group is unclear. Possible explanations include a possible relation to the chromophore or perhaps an effect of packaging material," they said.

The study is published in the April issue of Journal of the American Association for Pediatric Ophthalmology and Strabismus.