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Study finds increased incidence of OHT among Grave's orbitopathy patients

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Patients with thyroid-related immune orbitopathy, or Grave's orbitopathy, have a higher prevalence of ocular hypertension compared with age- and gender-matched patients without the disease, a study found.

Zohreh Behrouzi, MD, and colleagues investigated the prevalence of open-angle glaucoma (OAG), glaucoma suspects and ocular hypertension (OHT) in 233 eyes of 117 patients with thyroid-related immune orbitopathy (TRIO). They compared their findings to a control group of 240 eyes of 120 normal patients matched for age and gender, according to the study.

The researchers found a 2.5% rate of OAG and an 8.5% rate of OHT in TRIO patients. However, only two eyes in the control group had OAG, and none had either OHT or Grave's orbitopathy.

"Although the prevalence of OAG and [glaucoma suspects] were higher in [TRIO patients] than controls, this difference was not statistically significant," the authors said in the study.

They noted that OHT was significantly more common in the TRIO patients and that 10 eyes in this group (4.3%) developed compressive optic neuropathy, five (2.1%) of which also had high IOP.

The study is published in the June/July issue of Journal of Glaucoma.