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Study finds factors related to vision-related quality of life in pituitary adenoma patients
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The poor vision-related quality of life reported among patients with pituitary adenoma may be associated with the degree of visual field defects in the better-seeing eye and the duration of ocular symptoms, a prospective study by researchers in Japan suggests.
Fumiki Okamoto, MD, PhD, and colleagues administered the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) to 154 patients with presurgical pituitary adenoma. The influence of various factors – such as age, logMAR best corrected visual acuity, critical flicker fusion frequency, Humphrey static perimetry scores and duration of ocular symptoms – on quality-of-life scores were then compared with scores for 81 normal subjects.
The VFQ-25 composite score for patients with pituitary adenoma was significantly lower than the composite score for controls (P < .001); color vision was the only subscale that did not reveal a significant difference between the two groups, the authors noted.
The investigators found a significant correlation between the VFQ-25 composite score in patients with pituitary adenoma and logMAR BCVA, mean deviation and corrected pattern standard deviation of Humphrey perimetry, critical flicker fusion frequency, as well as the duration of ocular symptoms.
According to stepwise multiple regression analysis, the mean deviation score in the better-seeing eye (P < .001) and the duration of ocular symptoms due to pituitary adenoma (P < .001) were significantly linked to the VFQ-25 composite score, according to the study.
"These findings can provide useful information in the total treatment of patients with pituitary adenoma in practice," the study authors said in the August issue of American Journal of Ophthalmology.