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Study evaluates inflammation markers in Sjögren's patients

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SAN DIEGO — Women with Sjögren's syndrome have significantly higher white blood cell counts than men, according to a study presented here at the American Academy of Optometry meeting.

Barbara Caffrey, OD, of Toronto retrospectively reviewed the charts of 185 people with Sjögren's syndrome and collected serum from the patients to determine the difference in inflammation markers.

“One of the problems in analyzing sex differences in this disease is that very few men have Sjögren's syndrome,” Dr. Caffrey said. “Clinical wisdom is that women have higher serum levels of inflammatory markers.”

The study found that among the 170 women and 15 men analyzed, there were no differences in the amounts of monoclonal antibodies, antinuclear antibodies, rheumatoid factor, smooth muscle antibodies and immunoglobulin A. There was a significant difference in the white blood cell counts, with men showing a mean count of 3.7 and women showing a mean count of 5.2.