April 15, 2008
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Study: Corticocapsular adhesions associated with older age, female gender, cortical cataracts

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Cortical cataracts, older age and female gender appear to be potential factors for developing corticocapsular adhesions, according to a study by researchers in India, published in the March/April edition of Indian Journal of Ophthalmology.

"To reduce morbidity, identification of associations with [corticocapsular adhesions] can be helpful in appropriately modifying the [cataract surgery] procedure," the authors said.

Abhay R. Vasavada, MD, and colleagues at Iladevi Cataract and IOL Research Center in Ahmedabad studied 580 patients who received standardized phacoemulsification and were evaluated for probable risks associated with the development of corticocapsular adhesions. Specifically, 189 patients had corticocapsular adhesions (CCA) and 391 control patients had no CCA.

Patients in the CCA group averaged 64.71 years of age (ranging from 40 to 88 years), while patients in the control group averaged 59.27 years of age (ranging from 40 to 77 years), the authors noted.

Of 580 total patients, 318 patients were men, of which 93 (29.2%) had CCA; of 262 female patients, 96 (36.6%) had CCA.

Among patients aged between 40 and 49 years, 59 (22%) had CCA. However, among patients aged between 70 and 79 years, 110 (70%) had CCA, the researchers reported.

After adjusting for other factors, multivariate logistic regression analysis showed that the probability of CCA occurrence increased by 3.3% with advancing age (P = .028), according to the study.

Women were at an 83% higher risk of developing CCA than men (P = .027).

The investigators also found that the presence of anterior cortical cataract increased the odds of developing CCA by 9.5 times (P = .001), while posterior cortical cataract increased the odds by 3.3 times (P = .001), according to the study.