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Study: Change in oxygen parameters decreased ROP incidence

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ORLANDO, Fla. – A change in oxygen parameters for premature infants “dramatically decreased” the incidence of retinopathy of prematurity, according to a study presented here at the meeting of the American Association for Pediatric Ophthalmology and Strabismus.

Deborah K. VanderVeen, MD, and colleagues at Brigham and Women’s Children’s Hospital Boston, reported the outcomes of a 2003 study in a poster presentation at the meeting. Their study compared 5-year data for infants born weighing 1250 grams or less or at gestational age 28 weeks or less. The infants were treated either with conventional oxygen parameters or with new oxygen parameters with a target saturation of 90% to 92%.

“After the oxygenation policy change, there was a 60% reduction in severe ROP, and there was a trend toward a decrease in the incidence of any ROP,” study authors said. A reduction in incidence of prethreshold and threshold ROP was associated with a significant decrease of infant mortality, the authors said.