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Study: Adjusting IOP for CCT does not appear to affect glaucoma prevalence

Am J Ophthalmol. 2008;146(5):741-746.

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Calculating the impact of central corneal thickness on IOP levels through correction algorithms appears to not affect the prevalence of open-angle glaucoma, but CCT remains an important risk factor for the disease, a study found.

"Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of [open-angle glaucoma] and IOP," the study authors said.

They conducted a population-based cross-sectional study of 5,970 subjects in the Los Angeles Latino Eye Study who had no history of glaucoma treatment.

The prevalence of open-angle glaucoma and IOP was compared with CCT, which was measured as thin, normal or thick.

The researchers found that when stratified for CCT, subjects with thinner CCT had a significantly higher prevalence of open-angle glaucoma than subjects with normal or thick CCT measurements at all IOP levels.