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Stromal opacities seen after LASIK similar to PRK haze under confocal microscopy

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Focal wound-healing reactions can result in opacities in the central flap stroma and interface in some LASIK patients, according to a study. Under confocal microscopy, the opacities appear similar to post-photorefractive keratectomy haze, the study authors said.

Jens Bühren, MD, and Thomas Kohnen, MD, examined 18 eyes of 11 patients with clinically apparent corneal clouding 1 to 9 months after initial or re-treatment LASIK had been performed.

Postoperative slit-lamp examination showed faint, white, snowflake-like clouding at the interface level in all patients. One patient had folds and diffuse haze-like opacities. Confocal microscopy showed highly reflective structures in the flap stroma and at the interface level in all patients, probably resulting from significant keratocyte activation, the authors said.