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Stromal dystrophies likely to recur after PK, study finds

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PHILADELPHIA — The corneal dystrophies with the highest rate of simple recurrence after corneal graft are Bowman’s membrane dystrophy, granular and lattice dystrophies, according to a study.

Alexandre Marcon, MD, and colleagues at Wills Eye Hospital here identified all patients with stromal corneal dystrophies who underwent penetrating keratoplasty between 1984 and 2001. The study included 35 eyes with lattice dystrophy, 17 eyes with corneal dystrophy of Bowman’s membrane (CDB), 14 eyes with macular dystrophy, seven eyes with granular dystrophy and four eyes with Schnyder’s crystalline dystrophy.

Simple recurrence occurred in 60% of the eyes with lattice dystrophy and in 88% of the eyes with CDB. The median time to simple recurrence was 8.4 years for lattice dystrophy and 2 years for CDB. After a 5-year follow-up, there was clinically significant recurrence of the dystrophy in the first eye transplanted of each patient with lattice and CDB.

The study is published in the January issue of Cornea.