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Spontaneously resolved primary congenital glaucoma cases share characteristics

J Pediatr Ophthalmol Strabismus. 2009;46(3):139-143.

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While the reason for spontaneous resolution of primary congenital glaucoma is still unknown, nine resolved cases in a case review shared certain characteristics.

"The anterior segment findings in patients with spontaneous resolution of [primary congenital glaucoma] are similar to those of patients with treated [primary congenital glaucoma], the intraocular pressures are normal, the optic nerve damage is stable, and the filtration angles possess mild or moderate abnormalities," the study authors said.

Researchers reviewed medical records of 356 primary congenital glaucoma patients. After 4 months of age, nine patients showed spontaneous resolution of primary congenital glaucoma without glaucoma medication or surgery.

Of those nine subjects, 14 eyes showed evidence of early glaucoma and normal IOP, with a spontaneous resolution of primary congenital glaucoma. The 14 eyes had deep anterior chambers, clear lenses and angles that were abnormal for primary congenital glaucoma.

All affected eyes had large corneas, while 10 of the 14 eyes had Haab's striae, the authors said.