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Spectral analysis “promising” in glaucoma research

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BIRMINGHAM, Ala. — Spectral analysis of the intraocular pressure pulse is "promising" as a technique to investigate glaucoma as a vascular disease, according to a small study.

Researchers here used a pneumotonometer to take continuous IOP recordings from 10 patients with glaucoma and 10 normal subjects. The IOP recordings were then analyzed using the fast Fourier transform (FFT) to determine their spectral components. Although standard measurements of the IOP pulse (such as pulse amplitude) were insignificant, the second (P = .034), third (P = .015) and fourth (P = .013) harmonics of the waveform successfully differentiated between the glaucoma and normal groups.

The study is published in Graefe's Archive for Clinical and Experimental Ophthalmology.