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Speckle noise-reduced SD-OCT obtains clear measurement of macular ganglion cell layer
Ophthalmology. 2011:118(12);2412-2426.
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The macular ganglion cell layer can be accurately measured using speckle noise-reduced spectral domain optical coherence tomography B-scan imaging in eyes with preperimetric glaucoma, according to a study.
"Speckle noise-reduced SD-OCT imaging allowed clear visualization and measurement of the macular [ganglion cell layer], which was severely thinned in eyes with preperimetric glaucoma," the researchers said.
They conducted a retrospective, consecutive case series to evaluate macular ganglion cell layer thickness in 39 normal eyes and 37 eyes with preperimetric glaucoma. All subjects were imaged with the Spectralis SD-OCT (Heidelberg Engineering) at Kyoto University Hospital in Japan between July 2008 and June 2009.
The researchers used vertical and horizontal speckle noise-reduced SD-OCT to obtain and average 50 B-scans at identical locations of interest.
Results indicated that among patients with preperimetric glaucoma, thinning of the macular ganglion cell layer was visually apparent, especially on vertical scans.
"The mean regional macular [ganglion cell layer] was most severely thinned in the inferior perifoveal region, where its thickness was [less than] 70% of its normal thickness in 30 (81.1%) of the 37 eyes and [less than] 50% of its normal thickness in 13 (35.1%) of the 37 eyes," the study authors said.