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Soft contact lens materials not effective for drug delivery

Eye Contact Lens. 2008;34(5):266-271.

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The time course for uptake and release was too fast for effective drug delivery when ciprofloxacin was tested for topical extended release from soft contact lens materials.

Six commercially available silicone hydrogel contact lens types and three conventional soft contact lens types in their original packaging were evaluated for their usefulness in the long-term delivery of topical ciprofloxacin hydrochloride. The majority of lenses released their drug within the first 10 to 15 minutes.

Silicone hydrogel materials tested were balafilcon A (PureVision, Bausch & Lomb), comfilcon A (Biofinity, CooperVision), galyfilcon A (Acuvue Advance, Johnson & Johnson), lotrafilcon A (Night & Day, CIBA Vision), lotrafilcon B (O2 Optix, CIBA Vision) and senofilcon A (Acuvue Oasys, Johnson & Johnson). Conventional materials were alphafilcon A (SofLens 66, Bausch & Lomb), etafilcon A (Acuvue2, Johnson & Johnson) and polymacon (SofLens 38, Bausch & Lomb).

Of the silicone hydrogel materials, balafilcon A released the most drug and appears to be the most encouraging for high delivery levels, the researchers said.