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Single triamcinolone injection controls post-vitrectomy inflammation
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Administering a single posterior sub-Tenon injection of triamcinolone acetonide controls intraocular inflammation after pars plana vitrectomy as effectively as a 4-week regimen of topical prednisolone acetate, a randomized study shows.
Letícia Paccola, MD, and colleagues in Brazil and the United States compared the safety and anti-inflammatory efficacy between the two drugs in 40 consecutive phakic eyes of 40 patients. All patients underwent pars plana vitrectomy for non-clearing vitreous hemorrhage with an attached retina, epiretinal membrane or macular hole, according to the study.
After surgery, the researchers randomly assigned eyes to receive either a single posterior sub-Tenon injection of 40 mg triamcinolone plus sham eye drops or a sham injection plus 1% prednisolone acetate eye drops, according to the study.
The researchers observed no difference in the severity of anterior chamber cell and flare between the two groups at any point during the study period. Both groups had similar significant decreases in anterior chamber cell and flare out to 28 days follow-up, the authors reported.
Additionally, no differences in pain, photophobia, conjunctival erythema, ciliary flush or chemosis scores were identified between the two groups, the authors noted.
The study is published in the September issue of Acta Ophthalmologica Scandinavica.