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Silicone oil linked to increased risk of surgical failure in glaucoma valve cases

J Glaucoma. 2009;18(4):325-330.

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While implanting the Ahmed glaucoma valve with or without silicone oil injection results in equally effective IOP control, the use of silicone oil increases the risk of surgical failure, a study found.

The multicenter, retrospective study compared results of surgical outcomes after pars plana vitrectomy and valve implantation in 94 patients; 47 received silicone oil injection and 47 did not receive silicone oil. Follow-up was a mean of 2 years.

The study authors found that the Cox hazard model cited silicone oil as a significant risk factor for surgical failure (risk ratio= 3.43; P = .04).

"The cumulative probability of success by life-table analysis was 85% at 6 months, 80% at 1 year, 70% at 2 and 3 years, and 47% at 4 years in the silicone oil group, and 100% at 6 months and 1 year, and 76% at 2, 3 and 4 years in the control group (P = .03)," the authors said

At last follow-up, the mean IOP and glaucoma medications were comparable in both the silicone and non-silicone groups, they said. Also, complications were comparable in both groups.