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Silicone-, hydrogel-based contacts interact similarly with ciprofloxacin
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Both silicone-based and conventional hydrogel contact lenses may be viable options as corneal bandages, according to an in vitro study. The differences in ciprofloxacin uptake and release between the two types of lenses may not be clinically significant, the study authors say.
C.C.S. Karlgard, MASc, and colleagues with the Centre for Contact Lens Research in Ontario studied silicone-based hydrogel and conventional hydrogel contact lenses to determine their usefulness as corneal bandages by measuring the in vitro uptake and release of ciprofloxacin.
The lenses showed similar drug uptake but different levels of drug release. The silicone-based hydrogel lenses released a lower amount of drug than the conventional hydrogel lenses (72 µg per lens vs. 168 µg per lens, respectively). The study authors noted that this difference may not be clinically significant because both levels exceed the MIC90 of ciprofloxacin for common ocular pathogens.
The study is published in Eye & Contact Lens: Science and Clinical Practice.