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Signal curves, corneal biomechanical properties factor into keratoconus screening

Invest Ophthalmol Vis Sci. 2009;doi:10.1169/iovs.09-4304.

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Corneal biomechanical factors alone are not sufficient to identify keratoconus suspect corneas and prevent corneal ectasia after LASIK, according to a study.

"Analyzing signal curves obtained with the [Ocular Response Analyzer, Reichert] device may provide additional valuable information to select qualified patients for refractive surgery," the study authors said.

The retrospective study included 252 normal eyes, 80 keratoconus suspect eyes and 172 keratoconus eyes. Investigators used the ORA to measure corneal hysteresis (CH) and corneal resistance factor (CRF), two key corneal biomechanical properties.

Study data showed CH of 10.6 mm Hg in the normal cornea group, 10 mm Hg in the suspected keratoconus group and 8.1 mm Hg in the keratoconic cornea group. Mean CRF was 10.6 mm Hg in the normal cornea group, 9.7 mm Hg in the suspected keratoconus group and 7.1 mm Hg in the keratoconic cornea group.

"The mean CH and CRF were significantly different between the three groups," the authors said. The differences were statistically significant (P < .001).