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Sharp-edged Sensar IOL leads to less PCO than round-edged version, study finds
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VIENNA, Austria — The sharp-edged design of the Sensar OptiEdge AR40e IOL led to significantly less posterior capsule opacification than the Sensar AR40 IOL at 1 year postop, a randomized study here found. The sharp-edged IOL was not associated with an increase in glare symptoms, the study authors reported.
Researchers at the University of Vienna here randomized 106 eyes of 53 patients with bilateral age-related cataract. Each patient received a Sensar AR40 IOL (Advanced Medical Optics) in one eye and a Sensar AR40e IOL (AMO) in the other eye.
The AR40 has rounded edges, while the AR40e has a rounded anterior edge and a square posterior edge design.
Regeneratory posterior capsule opacification (PCO) was statistically significantly higher in the AR40 group than in the AR40e group (P < .05) beginning at 6 months postop. Posterior fibrotic PCO was also significantly higher in the AR40 group at 1 month. In no case was the amount of regeneratory PCO higher in the AR40e eye.
Sixteen of 45 patients had the same amount of regeneratory PCO in both eyes, and 20 (64%) had less regeneratory PCO in the AR40e eye. Seven patients (16%) had slightly more fibrotic PCO in the AR40e eye and 16 patients had significantly more fibrotic PCO in the AR40 eye.
There was no significant difference between the two IOLs in Snellen best corrected visual acuity measurements.
Aside from the optic edge design, the two IOLs are identical, leaving study authors to conclude the modified lens design of the AR40e is the explanation for its significantly lower PCO rates. “Whether this is because of delayed development of, or a permanent reduction in, PCO will become more clear with longer follow-up,” they conclude in the July issue of the Journal of Cataract & Refractive Surgery.