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Severity of Fuchs' endothelial corneal dystrophy influences central corneal thickness
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FORT LAUDERDALE, Fla. — Central corneal thickness increases with the severity of Fuchs' endothelial corneal dystrophy, according to a poster presentation here.
"Increasing thickness at lower grades suggests the balance between increasing endothelial permeability and endothelial pumping function may be disturbed at an earlier phase of disease than previously thought," Laura J. Kopplin, PhD, and colleagues said in a poster at the Association for Research in Vision and Ophthalmology meeting.
The study included 1,610 eyes of 969 subjects who were recruited as part of a study to determine genetic risk factors for Fuchs' endothelial corneal dystrophy primarily among siblings. Index cases, family members, and additional non-familial cases and controls were observed. Subjects underwent slit lamp biomicroscopy and received a Fuchs' endothelial corneal dystrophy grade from 0 (no guttae) to 6 (more than 5 mm confluent guttae with corneal edema).
A multivariable model determined that CCT in index cases was thicker than in the controls at all grade levels (P < .01). Index cases also had significantly thicker CCT than affected family members for grades 1 to 5, the poster said.
CCT in affected family members was thicker than in unaffected family members for grades 4 to 6.
In addition, CCT was found to be associated with increased IOP, the poster said.
- Disclosure: Dr. Kopplin has no direct financial interests to disclose.