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Selection bias in studies may affect risk of glaucomatous vision loss

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Selection bias may artificially reduce the risk of glaucomatous visual field loss in patients enrolled in longitudinal studies, according to a study.

David B. Henson, PhD, and colleague Siddesh Shambhu, MSc, MBBS, of the University of Manchester, England, compared the visual field records of 66 glaucomatous eyes enrolled in a prospective longitudinal study to 66 eyes of patients not enrolled in a study.

All eyes were matched based on enrollment time, duration of follow-up and extent of visual field loss, the authors noted.

The researchers found that patients not enrolled in a longitudinal study had a 368% higher relative risk of progressive visual field loss, according to the study.

The study is published in the October issue of Archives of Ophthalmology.