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Segmentation error hinders OCT measurement
Invest Ophthalmol Vis Sci. 2009;50(1):399-404.
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Segmentation error in optical coherence tomography for patients undergoing treatment for neovascular age-related macular degeneration proved problematic. The error rate was reduced with repeated imaging, but it was not eliminated.
“These findings are important, as quantitative change in retinal thickness measurements is one of the criteria used to guide anti-VEGF re-treatment,” the study said.
The study included 50 eyes of 50 patients with a mean age of 80 years (range, 64 years to 91 years). Mean visual acuity was an ETDRS score of 48 letters (range, five to 75 letters). Scanning was performed with the Stratus OCT (Carl Zeiss Meditec).
Investigators found segmentation error in 45 patients (90%); error affected the central 1-mm subfield in 37 patients (74%).
They attributed most segmentation error to failure of the OCT machine’s algorithm.
“[We] recommend manual measurement of central macular thickness when two or more line scans are affected by segmentation error in the central 1-mm subfield,” the study authors said.