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Sedative may not alter IOP measurement in children

Br J Ophthalmol. 2011;95(8):1102-1105.

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Using midazolam to sedate children in order to obtain IOP measurements may be safe and well tolerated, a study found.

“In the present study, we did not find any relevant impact of midazolam on IOP when administered orally in children at a dosage of 1 mg/kg,” the study authors said.

In the prospective study, researchers measured IOP in 72 eyes of 36 children without glaucoma. IOP was measured before midazolam was administered, at 15 and 30 minutes after midazolam administration, and at 5 and 15 minutes after general anesthesia was given.

The mean IOP measured at baseline was 11.2 mm Hg, and no statistically significant changes were seen in measurements obtained after administration of midazolam. At 5 and 15 minutes after administration of general anesthesia, however, there was a statistically significant decline in IOP (P < .0001).

No complications related to midazolam were observed during testing.