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Scanning laser ophthalmoscopy-based scoring system may predict glaucoma progression
Ophthalmol. 2010;117(9):1674-1683.
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A Glaucoma Predictability Score generated from confocal scanning laser ophthalmoscopy may be useful in predicting the risk of progression to primary open-angle glaucoma, according to a study.
In a study of 857 eyes of 438 participants in the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertensive Treatment Study followed with the imaging modality, 64 eyes of 50 patients progressed to primary open-angle glaucoma after a median of 72.3 months.
"In both univariate and multivariable analyses, baseline [glaucoma predictability score] indices were significantly associated with the development of POAG," the study authors wrote.
The glaucoma predictive score (GPS), available with Heidelberg Retinal Tomography, uses geometric modeling to map the contours of the optic disc and parapapillary retina based on cup size and depth, rim steepness, and horizontal and vertical retinal nerve fiber layer curvature. The scoring system, which computes a predictive primary open-angle glaucoma score on a percentage scale, does not rely on an operator-drawn contour or reference plane and is therefore operator-independent, the authors noted.
Additionally, models based on the Moorfields regression analysis (MRA) and stereometric parameters were similarly predictive compared with modeling using stereophotograph-based horizontal cup-to-disc ratio. In sum, the "results suggest that the HRT GPS, MRA and cup-to-disc ratio can be substituted for stereophotograph-based measures to estimate the risk of developing glaucoma in ocular hypertensive eyes," according to the study.