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‘Scaffold-enhanced’ bioadhesive sufficient for strabismus surgery, study suggests
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A “scaffold-enhanced” bioadhesive composite has enough strength to be used in strabismus surgery instead of sutures, an animal study suggests.
Mark T. Duffy, MD, PhD, and colleagues at the University of Illinois College of Medicine evaluated a bioadhesive composite for use as an alternative to sutures. The bioadhesive consisted of a cyanoacrylate glue combined with either a poly(L-lactic-co-glycolic acid) scaffold or a rehydrated porcine small intestine submucosa scaffold. The bioadhesives were used to produce rectus-muscle-to-sclera, sclera-to-sclera and rectus-muscle-to-rectus-muscle adhesions in 40 rabbits.
In all cases, the scaffold-enhanced cyanoacrylate adhesions were significantly stronger than cyanoacrylate alone. The rectus-muscle-to-sclera adhesions were greater than the in vivo forces reported for the horizontal rectus muscles in humans in extreme gaze, the researchers said.
The study is published in the August issue of the Journal of American Association for Pediatric Ophthalmology and Strabismus.