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ROP risk may be largely determined by genetics

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Genetics appears to play a significant role in predisposing infants to develop retinopathy of prematurity, according to a study by researchers at Yale School of Medicine.

Vineet Bhandari, MD, and colleagues retrospectively studied the contributing risk factors for retinopathy of prematurity (ROP) in 200 twins born after an average of 29 weeks gestation.

Using mixed-effects logistic regression analysis, the researchers found that gestational age and duration of supplemental oxygen were significant risk factors for ROP. However, after controlling for known and unknown nongenetic factors, genetics accounted for 70.1% of the ROP risk, according to the study.

Future interventional models for ROP should limit environmental risks and should identify and target genetic factors, Dr. Bhandari said in a press release from Yale.

The study is published in the journal Pediatrics.