February 19, 2007
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Risk of glaucoma progression independent of CCT

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DANA POINT, Calif. — The risk of glaucoma progression seems to be independent of central corneal thickness, according to a speaker here.

Studies have shown that central corneal thickness (CCT) "bears an inverse relation with the risk of developing glaucoma damage," said Leon W. Herndon, MD, at the Ocular Drug and Surgical Therapy Update.

"Risk of glaucoma progression, however, seems to be independent of central corneal thickness," Dr. Herndon said.

Evolving tonometry techniques may provide new paradigms that could result in more accurate risk stratifications for glaucoma patients, he said.

Dr. Herndon and colleagues studied more than 200 patients to determine if CCT is related to glaucoma severity at its first presentation with a glaucoma specialist. They performed a statistical analysis using univariable and multivariable modeling with several common predictor variables such as age, sex, race, IOP and CCT.

"Suffice it to say, having a thin central corneal thickness predicts the worst outcome much more so than other predictor variables," Dr. Herndon said.