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Risk of donor endothelial failure increases in donor dislocation cases

Cornea. 2008;27(10):1114-1118.

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After endothelial keratoplasty, the risk of donor endothelial failure is increased in cases of donor dislocation, and open communication between the anterior and posterior chambers can increase the occurrence of donor dislocation, a study found.

Donor dislocation was significantly more common (P = .017) in eyes that had an open communication between the anterior and posterior chambers, occurring in 11 of 25 cases studied (44%) compared with 12 of 64 cases (19%) that had an intact iris/lens diaphragm, according to the study.

The researchers also found that early endothelial failure was significantly more common (P = .011) in cases that needed additional surgical intervention for donor dislocation.

The retrospective review focused on 93 eyes of 85 patients, with complete data sets for analysis of 89 eyes; 77 cases had Descemet's stripping endothelial keratoplasty and 16 cases had Descemet's stripping automated endothelial keratoplasty. Median follow-up was 7 months.