This article is more than 5 years old. Information may no longer be current.
Researchers document cluster of uveitis after receipt of intravitreal anti-VEGF
Ophthalmic Surg Lasers Imaging. 2011;42(4):292-296
Click Here to Manage Email Alerts
Researchers identified seven cases of noninfectious bevacizumab-related uveitis that occurred between May 2009 and August 2009.
Seven eyes of six patients developed noninfectious uveitis after Avastin (bevacizumab, Genentech) intravitreal injections out of 978 consecutive bevacizumab injections, according to results of a retrospective case series.
All seven eyes had been previously treated with about 6.1 bevacizumab injections (range: three to 12).
Mean age of the affected patients was 74.6 years (range: 26 to 92 years), and all patients developed symptoms within 1 day of receiving the injection. Corneal edema, anterior chamber and vitreous cell, conjunctival injection, ocular pain and lack of hypopyon were among the signs and symptoms identified.
Despite these signs and symptoms, all patients regained visual acuity to within one line of baseline acuity.
"Acute onset of symptoms, absence of hypopyon, a predominant anterior segment reaction, and prompt improvement on topical steroid therapy are useful clinical features distinguishing this uveitic syndrome from infectious endophthalmitis," the researchers suggested.