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Replacement iris optic more effective in traumatic aniridia
Ophthalmology. 2008;115(10):1705-1712.
An IOL designed to function like the iris in aniridia patients was significantly more effective in improving vision in patients with traumatic aniridia than in patients with congenital aniridia.
Researchers were able to predict with reasonable certainty the refractive correction in 40 eyes of 35 patients implanted with the black diaphragm IOL (Morcher). The mean biometry prediction error was –0.12 ± 0.44 D, with a mean absolute error of 1.47 ± 0.29 D, equivalent to 80% of target eyes being within 2 D of predicted error.
Overall, best corrected visual acuity improved a mean 0.56 logMAR, “approximately equivalent to a mean improvement in visual acuity from 20/400 to 20/100 on a Snellen chart,” the study said. However, subgroup analysis showed that BCVA improved in the 25 eyes with traumatic aniridia from 1.34 ± 0.22 logMAR to 0.54 ± 0.22 after implantation (P < .001), but in the 15 eyes with congenital aniridia, BCVA improved from 1.17 ± 0.14 to 1.01 ± 0.21 logMAR after implantation.
The study authors also reported a significant association with glaucoma among patients implanted with the black diaphragm IOL. The number of patients being treated for glaucoma rose from 10 before surgery (25%) to 22 (55%) after surgery.