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Remifentanil, fentanyl have equal effects on IOP intraoperatively

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Remifentanil and fentanyl both maintain IOP at an equally reduced level during nonophthalmic surgery, according to a study.

A group of researchers at the University of Vienna, Austria, randomized 32 patients to receive either a continuous infusion of remifentanil or an intermittent bolus of fentanyl during anesthesia maintenance in nonophthalmic surgery. IOP was determined preoperatively, during the maintenance of anesthesia, 2 minutes after emergence and in the recovery room.

After anesthesia was induced, a significant decrease in IOP was seen in the remifentanil group, with IOP dropping from 13.6 mm Hg preop to 7.1 mm Hg intraoperatively. In patients assigned to the fentanyl group, mean IOP dropped from 13.7 mm Hg preop to 9.7 mm Hg intraoperatively. Thirty minutes after the end of anesthesia, IOPs in both groups returned to baseline levels.

The study is published in the European Journal of Anaesthesiology.