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Ramosetron effective in preventing vomiting after strabismus surgery

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A new serotonin agonist, ramosetron, was effective in preventing vomiting after strabismus surgery in children, Japanese researchers found. A 6-µm/kg dose of ramosetron was more effective than a 3-µm/kg dose in preventing vomiting, and a 12-µm/kg dose was no more effective, according to their study.

Yoshitaka Fujii, MD, and colleagues at Toride Kyodo General Hospital randomized 80 children scheduled for strabismus surgery to receive either placebo or ramosetron at one of three doses: 3 µg/kg, 6 µg/kg or 12 µg/kg.

The rate of patients who did not retch or vomit during the 0- to 24-hour period after anesthesia was 35% in the 3 µg group, 90% in the 6 µg group and 90% in the 12 µg group. The rates remained similar in the 24- to 48-hour period. No adverse events were reported.

The study is published in the January issue of Archives of Ophthalmology.