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Radiotherapy plus TTT provides ‘excellent’ tumor control

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PHILADELPHIA — Combining plaque radiotherapy and transpupillary thermotherapy results in “excellent” tumor control with a low recurrence rate in eyes with choroidal melanoma, a large study found.

Carol Shields, MD, and colleagues here with Wills Eye Hospital treated 270 patients with newly diagnosed choroidal melanoma with plaque radiotherapy followed by 3 sessions of TTT starting at plaque removal and continuing at 4-month intervals.

Tumor recurrence was 2% at 2 years follow-up and 3% at 5 years. Risk factors for recurrence included macular location of the tumor epicenter, diffuse tumor configuration and tumor margin extending underneath the foveola.

The study is published in the July issue of Archives of Ophthalmology.