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Rabbit study shows therapeutic levels of moxifloxacin at 12 hours
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Therapeutic levels of moxifloxacin were present in rabbit eyes at 12 hours after intravitreal injection, according to a recent study. The pharmacokinetic data suggest that intravitreal injection of the fluoroquinolone may have a role in the treatment of bacterial endophthalmitis, the study authors said.
Mohan N. Iyer and colleagues at Baylor College of Medicine administered intravitreal moxifloxacin injections of 200 µg/0.1 mL to phakic, uninflamed rabbit eyes. Four eyes were enucleated after 1, 6, 12, 24 and 36 hours each, and three eyes were enucleated after 48 hours. The eyes were frozen, and samples of frozen vitreous were obtained. Antibiotic assays were performed on the vitreous samples with high performance liquid chromatography.
The concentration of intravitreal moxifloxacin showed an exponential decay with a half-life of 1.72 hours, the study authors reported. The mean vitreous concentration was 120.49 µg/mL at 1 hour after injection, declining to 20.23 µg/mL at 6 hours and to 1.06 µg/mL at 12 hours.
“The concentrations achieved were several orders of magnitude greater than the [minimum inhibitory concentrations] of organisms commonly involved in bacterial endophthalmitis,” the authors said, and these therapeutic levels were maintained at 12 hours.
The study is published in the January issue of Investigative Ophthalmology & Visual Science.