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PVD correlated with age, myopic error in large study

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A large cohort study has shed light on the pathophysiology of posterior vitreous detachment and its role in the pathogenesis of various retinal and optic disc lesions. The study was undertaken by researchers at the University of Iowa and University of Heidelberg.

Sohan Singh Hayreh, MD, and Jost Jonas, MD, prospectively assessed the presence of posterior vitreous detachment (PVD) in 1,481 subjects with a mean age of 63.45 years and a mean spherical equivalent of +0.68 D. Main outcome measures included the frequency of PVD and its association with age, refractive error, cataract surgery, diabetes, arterial hypertension, history of ocular trauma and vitreous hemorrhage.

The occurrence of PVD was significantly associated with increasing age and with myopic refractive error female sex and surgical aphakia. PVD occurred more frequently bilaterally than unilaterally (P < .001). Patients with unilateral PVD were significantly younger than those with bilateral PVD. There was no significant association between the presence of PVD and macular hole, macular edema, retinal vascular occlusive disorders, age-related macular degeneration and open-angle glaucoma.

The study is published in Ophthalmologica.