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Pseudophakic corneal edema remains most common indication for PK

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Pseudophakic corneal edema remains the most common indication for penetrating keratoplasty, according to a retrospective chart review by researchers in Pennsylvania.

However, while the percentage of cases of pseudophakic corneal edema associated with posterior chamber IOLs has increased, the percentage of lens exchanges has declined, "perhaps reflecting increased confidence in biocompatibility of newer IOLs," the study authors said.

"The decrease in overall number of corneal transplants in these 5 years continues a trend noted in our previous study and mirrors the national decline in [PK]," they added.

In order to identify current indications and trends for PK and related procedures, Faris R. Ghosheh, MD, and colleagues at Wills Eye Institute in Philadelphia reviewed charts for 1,162 eyes that underwent PK between Jan. 1, 2001, and Dec. 31, 2005.

The most common indications for PK were pseudophakic corneal edema (330 eyes, 28.4%), regraft (250 eyes, 22%), keratoconus (186 eyes, 16%) and Fuchs' endothelial dystrophy (126 eyes, 10.8%), according to the study.

Of the 330 cases of pseudophakic corneal edema, 232 cases (70.3%) were linked to posterior chamber IOLs and 96 cases (29.1%) were associated with anterior chamber IOLs, the authors noted.

Seventy-six of these eyes (23%) received a lens exchange, and 246 eyes (74.5%) did not receive a lens exchange; 70 exchanged lenses were anterior chamber IOLs and six were posterior chamber IOLs.

Of the 70 exchanged anterior chamber IOLs, 10 were for scleral sutured IOLs, 18 were for posterior chamber IOLs and 42 were for another anterior chamber IOL, according to the study, published in the July issue of Eye & Contact Lens.