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Prostaglandins provide highest IOP reduction in angle-closure glaucoma cases
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BEIJING — When medically treating angle-closure glaucoma cases, prostaglandin analogues are the most effective means of lowering IOP, with greater reduction than beta-blocker or alpha-agonists, according to a speaker here.
Prin Rojanapongpun, MD, outlined medical treatment of angle-closure glaucoma at the 25th APAO Congress. He discussed numerous studies examining different medications in the prostaglandin class and the pressure lowering results in angle-closure glaucoma cases.
"There may be a slight difference in hypotensive efficacy and response rate, as well as safety profile, among different prostaglandins," he said.
There could be numerous reasons why prostaglandins are more effective than other drugs in treating angle-closure glaucoma cases, he said. One possibility is that prostaglandins could facilitate flow through the iris and ciliary body, or allow for a limited access of the uveoscleral channel.
He also outlined the steps in managing angle-closure glaucoma medical treatment, starting with documenting the angle closure, identifying mechanisms, beginning medical therapy or performing a laser peripheral iridotomy, reassessing the case after initial treatment and then monitoring the case.