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Prospective case series may confirm link between CRVO, exfoliation syndrome
Acta Ophthalmol. 2010;88(1):91-95.
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Patients with central retinal vein occlusion appear to be at greater risk for exfoliation syndrome, although the presence of exfoliation may not be readily apparent on clinical examination.
The association between the two, previously suggested in retrospective and histological studies, was noted in a prospective observational case series of 36 consecutive eyes of 36 patients with known CRVO. Overall, 22 patients (61%) demonstrated signs of exfoliation syndrome.
In the series, 12 patients had signs of exfoliation that were seen on slit lamp examination. Ten patients who showed no clinical signs of exfoliation had aggregates of exfoliation identified by conjunctival biopsy.
According to the study, patients with and without exfoliation were similar in age, gender, race and prevalence of systemic disorders. Before the development of CRVO in the 22 patients with concomitant exfoliation, 12 had no history of hypertension or glaucoma, according to the study.
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