November 25, 2010
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Progressive angle-narrowing may be important detection tool in normal tension glaucoma patients

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CHICAGO — Progressive angle-narrowing had a relative risk of 2.59 to field progression in a group of Chinese normal tension glaucoma patients, a study found.

Dexter Yu-lung Leung, MBChB, and colleagues examined 197 normal tension glaucoma (NTG) patients at the Hong Kong Eye Hospital who underwent dark room gonioscopy by a single investigator with 48-months follow-up.

He and his colleagues presented their results in a poster study at the joint meeting of the American Academy of Ophthalmology and Middle East Africa Council of Ophthalmology. They said that detection of progressive angle-narrowing "may be important in normal tension glaucoma."

"Twenty-six subjects (13.2%) had progressive angle-narrowing by at least 1 Shaffer grading in at least 2 quadrants," they said. "Mean Shaffer grading decreased by 0.30 in 85 field-progressed subjects, and by 0.27 in 112 field-stable subjects. Presence of this progressive narrowing conferred a relative risk of 2.59 to field progression. Long-term office pressure fluctuation was more in [the] progressive angle-narrowing group, conferring a relative risk of 1.15 mm Hg increase to field progression."