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Postop endothelial cell density more predictive of graft failure than preop density
Arch Ophthalmol. 2010;128(1):63-69.
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At 6 months after penetrating keratoplasty, central endothelial cell density was more predictive of graft failure from endothelial decompensation than preoperative endothelial cell density, a study found.
The study, a subset of the Cornea Donor Study, examined 483 grafts that did not fail and 17 grafts that failed from endothelial decompensation. Preop and postoperative endothelial cell densities were measured from specular images.
The study found that at 5 years follow-up, 40 of 277 subjects (14%) who had a clear graft also had endothelial cell density below 500 cells/mm².
"Among those that had not failed within the first 6 months, the 5-year cumulative incidence (±95% confidence interval) of failure was 13% (±12%) for the 33 participants with a 6-month endothelial cell density of less than 1,700 cells/mm² vs. 2% (±3%) for the 137 participants with a 6-month endothelial cell density of 2,500 cells/mm² or higher," the study authors said.