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Polysaccharide antigen can reduce S. epidermidis keratitis

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Immunization with a specific polysaccharide antigen reduces slime-producing Staphylococcus epidermidis keratitis in animal eyes, according to a Greek study.

C.D. Georgakopoulos and colleagues at the University of Patras immunized seven rabbits with 20-kDa PS, a major immunogenic polysaccharide determinant of slime, to determine if active immunization is more effective than passive immunization at preventing corneal damage. An additional seven rabbits received specific antibodies against 20-kDa PS, they said. Lesions were graded clinically for 21 days, according to a press release on the study.

The levels of the specific anti-20-kDa PS antibodies in serum and aqueous humor after either type of immunization were significantly higher when compared to those in the control group, researchers said. Both treated groups of rabbits had “significantly less corneal damage” when compared to the infected nontreated group, according to the study.

The study is published in Current Eye Research.