This article is more than 5 years old. Information may no longer be current.
Plasmin plus hyaluronidase induces PVD in rabbits
Click Here to Manage Email Alerts
Intravitreal injection of plasmin and hyaluronidase induced complete posterior vitreous detachment with no obvious toxicity in an animal study.
Zhi-Liang Wang, MD, and colleagues performed intravitreal injections in one eye each of 20 rabbits with a combination of plasmin and hyaluronidase; in 12 rabbits with plasmin alone; and in 12 rabbits with hyaluronidase alone. The fellow eye of each rabbit was injected with balanced salt solution to act as controls.
Scanning electron microscopy was performed on eight animals in each group at 7 days after injection. SEM showed that the eight rabbits that received hyaluronidase plus plasmin all had complete posterior vitreous detachment (PVD). Seven of the eight from the plasmin-alone group had partial PVD. In the hyaluronidase-alone group and the control eyes, no PVD was seen at 7 days.
The study is published in the January issue of Retina.