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Plaque radiotherapy for choroidal melanoma controls tumor in majority of cases

Arch Ophthalmol. 2008;126(11):1515-1522.

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When plaque radiotherapy was used in treating juxtapapillary choroidal melanoma overhanging the optic disc, local tumor control was achieved in 90% of cases, a study found.

However, the effects of the tumor and radiation resulted in poor visual acuity in 77% of the patients in the study.

All 141 patients in the retrospective medical record review study received plaque radiotherapy, using a notched design in 126 eyes, a round design in 14 eyes and a rectangular design in one eye, with iodine 125 in 132 eyes and cobalt 60 in nine eyes.

The metastatic rate was 13%, and the mortality rate was 3%.

"A final visual acuity of 20/200 or worse was measured in 72 eyes, and visual loss of more than five Snellen lines occurred in 59 eyes," researchers said.