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Pilot study: tranilast promising for filtering surgery

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KYOTO, Japan — Tranilast may be an effective adjunct to glaucoma filtering surgery, according to a pilot study here. Topical application of tranilast after filtering surgery alleviated ischemia of the filtering bleb, reduced intraocular pressure and increased the size of the bleb in this study.

Researchers here randomly assigned 52 eyes of 52 patients to receive either tranilast 0.5% eye drops (24 eyes) or a vehicle saline solution (28 eyes) four times daily for 3 months after trabeculectomy. Vascularization and size of the bleb as well as IOP were measured.

Six months after treatment, vascularization of the bleb was more common in the tranilast-treated eyes than in control eyes. The bleb was significantly larger at 6 and 12 months in the tranilast-treated eyes. The use of tranilast was not associated with any vision-threatening side effects.

The study is published in the April issue of Journal of Glaucoma.