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Photopic negative response of focal electroretinogram effective in detecting early glaucoma
Br J Ophthalmol. 2010;94:202-208.
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Using the photopic negative response of focal electroretinograms to detect glaucomatous change is a promising method of glaucoma detection, a study found.
In the study's combined criterion, for eyes considered glaucomatous when focal photopic negative response was "less than the cut-off values in either retinal area," results were even more promising.
"Focal [photopic negative responses] have diagnostic ability in detecting early glaucoma with high sensitivity and specificity, especially when the combined criterion is used," the study authors said.
The study looked at 114 eyes of 114 open-angle glaucoma patients and a control group of 42 eyes of 42 subjects without glaucoma. Focal electroretinograms were obtained with a 15° stimulus spot centered "on the macula, and on the superotemporal and on the inferotemporal areas of the macula."
The study found that focal photopic negative response amplitudes were significantly reduced by progressing glaucoma. For early glaucoma cases, photopic negative response sensitivities for each retinal area ranged from 58.1% to 80.7%. For combined criterion cases, sensitivities significantly increased.
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