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Photocoagulation helps reduce DME, permeability

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HERLEV, Denmark — A reduction of diabetic macular edema after photocoagulation is paralleled by a decrease in the passive permeability of the blood retinal barrier, according to a study.

Birgit Sander and colleagues at Herlev Hospital here prospectively studied 46 eyes of 34 patients with clinically significant macular edema who were undergoing photocoagulation treatment. Their aim was to quantitate the effect of photocoagulation on the blood-retinal barrier.

In 23 eyes, clinically significant macular edema was not present at 6-month follow-up. In 23 eyes it was still present. The passive transport (permeability) for responding eyes decreased significantly after photocoagulation, in contrast with an increase in the nonresponding eyes (P = .03). Active transport for the responding eyes decreased slightly at follow-up, while it increased for nonresponding eyes. The difference between the two groups at follow-up was not significant.

The study is published in the British Journal of Ophthalmology.