PDT may not stabilize visual acuity, lesion size in CNV, study shows
Photodynamic therapy with verteporfin does not appear to effectively stabilize visual acuity and lesion size in choroidal neovascularization secondary to angioid streaks, a study found.
Luis Arias and colleagues retrospectively studied 10 eyes of 10 consecutive patients with choroidal neovascularization (CNV) secondary to angioid streaks. All patients were treated with standard PDT with verteporfin protocol.
The study found that mean visual acuity was 20/126 at baseline (range 20/40 to 20/320) and 20/500 at the final examination. Three patients lost less than three lines of visual acuity and four patients lost six lines. In total, patients lost a mean of 4.9 lines, the authors said.
Overall, however, results in the PDT-treated group appeared to be slightly better than in a control group of seven previously examined patients who had not undergone PDT, the study found.
The mean duration of follow up in the PDT group was 18 months, while in the control group mean follow up was 15 months.
The study was published in Graefe’s Archive for Clinical and Experimental Ophthalmology.