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PDT effective for CNV secondary to inflammation
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Photodynamic therapy was effective in treatment of choroidal neovascularization secondary to inflammatory conditions in a German study. According to the study authors, PDT was more effective for this indication than for CNV secondary to age-related macular degeneration.
Joachim Wachtlin and colleagues at the Free University of Berlin prospectively studied the use of PDT with verteporfin in 19 patients with CNV due to inflammatory conditions including punctate inner choroidopathy, presumed ocular histoplasmosis syndrome, multifocal choroiditis and panuveitis. Follow-up was every 3 months for at least 1 year.
Mean change in visual acuity after a mean follow-up of 22 months was +1.6 lines using the Early Treatment of Diabetic Retinopathy Study guidelines. At the last visit, all eyes showed a disappearance of pretreatment leakage in fluorescein angiography, the authors said.
For juxtafoveal CNV, results were similar to those with subfoveal CNV with no additional safety concerns.
The study authors said, based on results of the study, they consider PDT the treatment of choice for subfoveal CNV secondary to inflammatory chorioretinal diseases and selected cases with juxtafoveal CNV.
The study is published in the November issue of Graefe’s Archive for Clinical and Experimental Ophthalmology.