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Patients with diabetes develop cataracts earlier than those without diabetes

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ZAGREB, Croatia — Advanced glycation end product formation distribution might play a role in degenerative changes in the eye, explaining why patients with diabetes are more likely to develop cataract more quickly than their non-diabetic counterparts, according to a study.

Zdenka Turk and colleagues at University Hospital Center evaluated advanced glycation end product (AGE) formation immunoreactivity in the lenses of 14 patients with diabetes and 31 patients without diabetes to determine if any relation in high-molecular-weight content existed.

Lenses without diabetes showed a significant correlation between lens AGE content and patient age. The level of non-specified AGEs measured in lenses with diabetes showed an overall increase compared to lenses without diabetes. Diabetic patients with higher levels of AGEs also showed a higher level of high-molecular-weight proteins.

The study is published in the April issue of Graefe’s Archive for Clinical and Experimental Ophthalmology.